Open Notebook Science in 15 minutes

update: transcript is available

On October 10, 2008 Jean-Claude Bradley presented a 15 minute summary of Open Notebook Science and its application to the synthesis of anti-malarial compounds as part of a mini-symposium on faculty research in the Chemistry department at Drexel University.

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Open Notebook Science in 15 minutes

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Open Notebook Science - Falcipain-2 Preliminary Results

This talk was presented by Jean-Claude Bradley at the American Chemical Society meeting in Philadelphia on August 20, 2008. An introduction to Open Notebook Science is presented followed by an illustration of how ONS can be used in drug discovery. New data relating to the anti-malarial activity of Ugi products on 2 falcipain-2 docking sites is detailed. The docking calculations were provided by Rajarshi Guha and the enzyme and in vitro assays on Plasmodium falciparum were provided by Phil Rosenthal and Jiri Gut. Most of the syntheses were carried out by Khalid Mirza in the Bradley group.
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Open Notebook Science and Preliminary Falcipain-2 Results

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NFAIS 2008 talk on Open Notebook Science

Jean-Claude Bradley presents on "Open Notebook Science: Putting the Information User in Control through Transparency" at the NFAIS meeting in Philadelphia on February 24, 2008. This was part of the session on "The Emerging Culture of the New Information Order". The use of public blogs, wikis, GoogleDocs and mailing lists to conduct research on the synthesis of new anti-malarial agents is described.

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